Smokers could one day be immunised against nicotine so they gain no pleasure from the habit, according to researchers in the US.

They have devised a vaccine that floods the body with an antibody to assault nicotine entering the body.

A study in mice, published in Science Translational Medicine, showed levels of the chemical in the brain were reduced by 85% after vaccination.

Years of research are still needed before it could be tested on people.

However, lead researcher Prof Ronald Crystal is convinced there will be benefits.

"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect."

New approach

Other "smoking vaccines" have been developed that train the immune system to produce antibodies that bind to nicotine - it is the same method used to vaccinate against diseases. The challenge has been to produce enough antibodies to stop the drug entering the brain and delivering its pleasurable hit.

Scientists at Weill Cornell Medical College have used a completely different approach, a gene-therapy vaccine, which they say is more promising.

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If they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit”

Prof Ronald CrystalWeill Cornell Medical College

A genetically modified virus containing the instructions for making nicotine antibodies is used to infect the liver. This turns the organ into a factory producing the antibodies.

The research team compared the amount of nicotine in the brains of normal mice with those that had been immunised. After being injected with nicotine, the vaccinated mice had nicotine levels 85% lower.

It is not known if this could be repeated in humans or if this level of reduction would be enough to help people quit.

Prof Crystal said that if such a vaccine could be developed then people "will know if they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit".

He added: "We are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today, but find their nicotine addiction to be strong enough to overcome these current approaches."

'Impressive and intriguing'

There are also issues around the safety of gene therapy in humans that will need to be answered.

Professor of genetics at the University of Kent, Darren Griffin, said the findings were "impressive and intriguing with great potential" but cautioned there were still many issues which needed addressing.

He said the main issue "is whether the observed biochemical effects in lab mice genuinely translate to a reduced addiction in humans given that such addictions can be both physical and psychological".

Dr Simon Waddington, from University College London, said: "The technology underpinning gene therapy is improving all the time and it is encouraging to see these preliminary results that indicate it could be used to address nicotine addiction, which is damaging to the nation's health and a drain on the health service economy."

If such a vaccine was developed it could also raise ethical questions about vaccinating people, possibly in childhood, before they even started smoking.

Coke and Pepsi contain tiny traces of alcohol, reveals French research

Coca-Cola and Pepsi contain minute traces of alcohol, scientific research published in France has revealed. The revelation will cause concern among those who chose the carbonated soft drink for religious, health or safety reasons. According to tests carried out by the Paris-based National Institute of Consumption (INC) more than half of leading colas contain the traces of alcohol. Can't beat the real thing: The revelation will cause concern among those who chose the carbonated soft drink for religious, health or safety reasons These include the brand leaders Coca-Cola and Pepsi Cola, while it is mainly only cheap supermarket versions of the drink which are alcohol-free. ‘60 Million Consumers’, the French magazine, publishes the results of the tests in its latest issue. They suggest that the alcohol levels are as low as 10mg in every litre, and this works out at around 0.001 per cent alcohol.

shooting a cop dead is now legal in the state of Indiana.

Governor Mitch Daniels, a Republican, has authorized changes to a 2006 legislation that legalizes the use of deadly force on a public servant — including an officer of the law — in cases of “unlawful intrusion.” Proponents of both the Second and Fourth Amendments — those that allow for the ownership of firearms and the security against unlawful searches, respectively — are celebrating the update by saying it ensures that residents are protected from authorities that abuse the powers of the badge. Others, however, fear that the alleged threat of a police state emergence will be replaced by an all-out warzone in Indiana. Under the latest changes of the so-called Castle Doctrine, state lawmakers agree “people have a right to defend themselves and third parties from physical harm and crime.” Rather than excluding officers of the law, however, any public servant is now subject to be met with deadly force if they unlawfully enter private property without clear justification. “In enacting this section, the general assembly finds and declares that it is the policy of this state to recognize the unique character of a citizen's home and to ensure that a citizen feels secure in his or her own home against unlawful intrusion by another individual or a public servant,” reads the legislation. Although critics have been quick to condemn the law for opening the door for assaults on police officers, supporters say that it is necessary to implement the ideals brought by America’s forefathers. Especially, argue some, since the Indiana Supreme Court almost eliminated the Fourth Amendment entirely last year. During the 2011 case of Barnes v. State of Indiana, the court ruled that a man who assaulted an officer dispatched to his house had broken the law before there was “no right to reasonably resist unlawful entry by police officers.” In turn, the National Rifle Association lobbied for an amendment to the Castle Doctrine to ensure that residents were protected from officers that abuse the law to grant themselves entry into private space. “There are bad legislators,” the law’s author, State Senator R. Michael Young (R) tells Bloomberg News. “There are bad clergy, bad doctors, bad teachers, and it’s these officers that we’re concerned about that when they act outside their scope and duty that the individual ought to have a right to protect themselves.” Governor Daniels agrees with the senator in a statement offered through his office, and notes that the law is only being established to cover rare incidents of police abuse that can escape the system without reprimand for officers or other persons that break the law to gain entry. “In the real world, there will almost never be a situation in which these extremely narrow conditions are met,” Daniels says. “This law is not an invitation to use violence or force against law enforcement officers.” Officers in Indiana aren’t necessarily on the same page, though. “If I pull over a car and I walk up to it and the guy shoots me, he’s going to say, ‘Well, he was trying to illegally enter my property,’” Sergeant Joseph Hubbard tells Bloomberg. “Somebody is going get away with killing a cop because of this law.” “It’s just a recipe for disaster,” Indiana State Fraternal Order of Police President Tim Downs adds. “It just puts a bounty on our heads.”

ON CLOUD NINE: BATH SALTS BY ANOTHER NAME... WITH STRONG COMPULSIONS TO REDOSE

After the recent stream of disturbing news reports of people eating others' flesh, Hornaday Manufacturing has released bullets that promise to ‘make dead permanent.’

The ammunition, branded as Zombie Max offers Proven Z-Max bullets, is live ammunition, but is actually only intended for use on targets – not people.

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The Walking Dead: Hornady Manufacturing has started selling Zombie bullets, 'just in case'; it is live ammunition

Attacks: Carl Jacquneaux, left, who was arrested for allegedly biting another man's face and Brandon De Leon, right, who allegedly tried to bite two policemen while threatening to eat them

 

Hornaday spokesman Everett Deger told WWJ Newsradio 950 that the company’s president has a love of zombie culture – including popular shows like the Walking Dead – and was inspired to make the bullets in honour of the cultural phenomenon. 

ON CLOUD NINE: BATH SALTS BY ANOTHER NAME... WITH STRONG COMPULSIONS TO REDOSE

The 'bath salts' sold under the name Cloud Nine are likely to be stimulant drugs such MPDV or ephedrine. 

'Bath salts' does not refer to a single chemical, but instead to a range of synthetic drugs that can be sold legally in the U.S. as long as they are not marked for human consumption – hence the misleading name.

Drugs such as MPDV are highly potent stimulants, similar to some amphetamines, and in MPDV's case particularly, cause a strong compulsion to 'redose' with more of the drug. 

In high doses, such drugs can cause violent and unpredictable behaviour, and terrifying hallucinations – and the compulsion to take more of the drug continues, even once the 'high' has begun to make the user feel bad.

Various different compounds use the name 'Cloud Nine', and it's still not confirmed which exact chemical was in the drug reported to have caused these attacks, but some reports have pointed the finger at MPDV. 

The chemical is already illegal in Florida – although other 'bath salts' remain perfectly legal in the state.  

 

‘We decided just to have some fun with a marketing plan that would allow us to create some ammunition designed for that…fictional world,’ he told the radio station.

Mr Deger noted that the bullets are some of the ammunition company’s most popular products.

The news comes as two more cannibal attacks have been reported in the US as police warn of a dangerous new mind-altering drug called Cloud Nine.

 

Last week Rudy Eugene - who is believed to have taken the over-the-counter ecstasy-like drug - growled at officers as he chewed off most of a homeless man's face before being shot dead by Miami police.

Since then two further incidents have been linked to the substance, which is part of a new line of 'bath salts'.

 

 

More...

• Revealed: Miami cannibal's girlfriend shows herself in public for the first time and claims her beau was carrying a BIBLE before the attack
• Caught on camera: The moment woman driver rams into pedestrian and travels for hundreds of yards with him clinging on 'because of her hormones'
• Revealed: The videos 'Canadian cannibal' sent to his 'fans' while on the run from police - and one of them contains infamous song from American Psycho

 

The second occurred on Saturday when a snarling homeless man, identified as Brandon De Leon, threatened to eat two officers, echoing the Miami attack.

A third incident took place in Louisiana where Carl Jacquneaux, 43, bit off a chunk of his victim's face. Miami police have issued a warning about Cloud Nine and told their officers to exercise extreme caution when dealing with homeless men who appear to be acting unusually.

Police investigating the case of Rudy Eugene, who ate the face off a homeless man, say as well as being naked, he was carrying a bible.

Some pages had been ripped out of the book and were found close by, according to CBS Miami. A preliminary toxicology examination has also found that the 31-year-old had been smoked cannabis shortly before the incident.

They were forced to fit 21-year-old De Leon with a Hannibal Lecter-style mask after he was arrested for disturbing the peace in North Miami Beach. When put in a police cruiser De Leon slammed his head against the plexiglass divider and shouted at officers, 'I'm going to eat you', NBC Miami reported. 

He then growled, gnashed his teeth and tried to bite the hand of an officer attempting to treat his head wounds.

'Brandon growled and opened and closed his jaw, slamming his teeth like an animal would,' the report said. Miami police said they believe he was on a cocktail of drugs, including Cloud Nine. 

In a second case Carl Jacquneaux, 43, is accused of attacking Todd Credeur at his home in Scott, Louisiana, over the weekend after he became upset following a domestic issue.

Victim: Todd Credeur, though in shock, managed to spray his attacker in the face with wasp spray to stop him from eating any more of his face

 

Scene: Todd Creneur was attacked while working on the yard outside his home in Scott, Louisiana

 

KATC reported that Mr Credeur was working in his front yard when he was attacked.

Scott Assistant Police Chief Kert Thomas said: 'During the attack, the suspect bit a chunk of the victim's face off.'

Mr Credeur reportedly managed to spray Jacquneaux in the face with wasp spray to stop him from eating any more of his face.

Jacquneaux then allegedly left the home and went to another man's home where he held him at knife point and stole a hand gun. This is where police found him and arrested him.

A friend of the victim said she believes Jacquneaux was under the influence of Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene.

Eugene ate the face of homeless man Ronald Poppo in Miami last week and a police memo to officers has highlighted the dangers surrounding the drug's use. 

It warned the De Leon case 'bears resemblance to an incident that occurred in the city of Miami last week, when a male ate another man's face'.

'Please be careful when dealing with the homeless population during your patrols.'

Police have suggested Eugene was under the influence of the synthetic stimulant usually sold in drug paraphanelia shops.

Cloud Nine is 'addictive and dangerous', the memo said, part of a 'disturbing trend in which new drugs are sold in the guise of household products'.

The drug, which is also as Ivory Wave in the U.S., comes in harmless-looking packets, police said, adding that it is illegal in Britain and Australia.

Crazed attack: Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene (left) when he savagely attacked 65-year-old Ronald Poppo (right)

The potentially addictive drug stimulates the central nervous system and symptoms include heart palpitations, nausea, hallucinations, paranoia and erratic behaviour.

The series of shocking incidents began on May 26 when a naked Eugene encountered his victim, 65-year-old Ronald Poppo, who was sleeping in the shade on elevated train tracks.

In surveillance footage from the nearby Miami Herald building, Eugene was seen struggling with the naked homeless man, throwing him to the ground and then tearing into his face with his teeth as cars and bicycles sped by.

About 18 minutes into the attack, an officer appeared on the scene and yelled at Eugene to stop, but the 31-year-old just growled at him and continued chewing Poppo’s face.

The officer then opened fire on Eugene, shooting him to death.

Enlarge 

Horrific attack: The spot on MacArthur Causeway when a man was killed after chewing the face off a stranger

 

Disfigured: Poppo, here on a stretcher, miraculously survived the attack, but was left without a nose, mouth or eyes

Poppo remains in critical condition at Jackson Memorial Hospital with his nose, mouth and eyes torn off. He faces months of treatment to rebuild his features and psychological care.

Controversially this week the scene of the attack on Poppo has been Miami added to sites visited by a tourist tour's itinerary.

The famous Miami Mystery & Mayhem: Crime Tour tour led by Miami-Dade College professor Dr Paul George will stop on the road that connects downtown Miami to popular South Beach.

Dr Paul told the South Florida Business Journal: 'Horrible as it was, it is part of our history. Currently, our tour takes us over the causeway right past the site, so this fits well.'

In a completely separate case not involving the drug, Canadian Luka Rocco Magnotta has been sent back to his country from Germany after an international manhunt.

He is alleged to have killed his partner, Jun Lin, before eating parts of his body then chopping it to pieces that were then posted to different authorities. Mr Lun's head has not yet been found.

'ZOMBIE APOCALYPSE': RECENT CANNIBAL ATTACKS ACROSS AMERICA

Since Rudy Eugene attacked and ate the face of homeless man Ronald Poppo on May 26 in Miami, Florida, while allegedly high on 'bath salts' there has been a spate of similar attacks.

The 'Miami Cannibal' case shocked the nation after police had to shoot dead Eugene when he refused to stop eating his victim's face off. Poppo is now recovering in hospital with horrific injuries.

 

Brandon DeLeon, 21, was high on drugs and drunk on Four Loko on June 2 when he tried to bite off a police officer’s hand after he was arrested for disturbing customers in a Miami fast food restaurant.

The homeless man repeatedly banged his head against the patrol car’s Plexiglas and yelled, ‘I’m going to eat you.’

At the police station, De Leon tried to bite the officer who was taking his blood pressure and tending to his self-inflicted wounds. The police report noted that he 'growled and opened and closed his jaw slamming his teeth like an animal would.'

 

Carl Jacquneaux, 43, is accused of attacking Todd Credeur at his home in Scott, Louisiana, over the weekend after he became upset following a domestic issue.

Mr Credeur reportedly managed to spray Jacquneaux in the face with wasp spray to stop him from eating any more of his face.

A friend of the victim said she believes Jacquneaux was under the influence of Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene.

 

Alex Kinyua, 21, a college student, used a knife to carve up Kujoe Bonsafo Agyei-Kodie, 37, before eating his heart out and parts of his brain.

He then took to his social networking site to boast about it to his friends saying: 'Are you strong enough to endure ritual HBCU mass human sacrifices around the country and still be able to function as human beings?'

He referred to the tragic shootings at Virginia Tech and 'other past university killings around the country' and warned 'ethnic cleansing is the policy, strategy and tactics that will affect you, directly or indirectly in the coming months.'

 

A mind-altering drug banned in Britain two years ago is being blamed for the spate of cannibal attacks in America.

Narcotic Cloud Nine was blamed for the attack when Rudy Eugene ate 75% of homeless man Ronald Poppo’s face in Miami last month.

Horrific images surfaced of the attack that only ended once police shot and killed 31-year-old Eugene.

Mr Poppo is still recovering from his injuries in hospital.

Police are now warning people to stay away from Cloud Nine – also known as ‘bath salts’ - after two similar attacks were reported.

The most recent prompted an internal memo to police warning officers the case “bears resemblance to an incident that occurred in the city of Miami last week, when a male ate another man’s face”.

The memo called the synthetic drug “addictive and dangerous” and said it was part of a “disturbing trend in which new drugs are sold in the guise of household products”.

It added: “Please be careful when dealing with the homeless population during your patrols.”

 

Rudy Eugene, 31: Ate 75% of a man's face in Miami before being shot dead

AP

Brandon De Leon, 21: Tried to bite two police officers after he was arrested in North Miami BeachCarl Jacquneaux, 43: Bit a man's face in Scott, Louisiania. Wasp spray was used to end the attackAlex Kinyua, 21: Accused of eating the heart and brain of friend in Maryland

Splash

Horror: Film cannibal Hannibal Lecter

Channel 5

 

During the latest attack homeless Brendon De Leon threatened to eat two Miami police officers and had to be fitted with a Hannibal Lecter-style mask to prevent him carrying his threats out.

He had been arrested for disturbing the peace in North Miami Beach while high on drugs and put in a police cruiser when he slammed his head against the plexiglass divider and shouted: “I’m going to eat you” to officers before growling and baring his teeth.

Miami police said they believe he was on a cocktail of drugs including Cloud Nine.

In another case, Carl Jacquneaux, 43, was accused of attacking Todd Credeur in his front garden in Scott, Louisiana, over the weekend after being upset over a domestic issue while under the influence of what is said to be bath salts.

Jacquneaux bit Mr Credeur before being sprayed in the face with wasp spray.

Scott Assistant Police Chief Kert Thomas said: “During the attack, the suspect bit a chunk of the victim’s face off.”

Jacquneaux was then said to have left the property and gone to another man’s home where he held him at knife-point and stole a handgun before being apprehended by police.

The drug, which is also known as Ivory Wave, was blamed for several deaths in Britain during 2010 before being banned. It is also illegal in Australia.

The potentially addictive drug stimulates the central nervous system and symptoms include heart palpitations, nausea, hallucinations, paranoia and erratic behaviour and is often sold in plain packaging with the contents purporting to be harmless.

Bank of England meets amid talk of £50bn stimulus

Bank of England policymakers meet today to decide whether to change interest rates or to pump in more money into the ailing economy, with leading economist saying they may opt to inject a further £50bn of stimulus.

Europe is on the verge of financial chaos.

Global capital markets, now the most powerful force on earth, are rapidly losing confidence in the financial coherence of the 17-nation euro zone. A market implosion there, like that triggered by Lehman Brothers collapse in 2008, may not be far off. Not only would that dismantle the euro zone, but it could also usher in another global economic slump: in effect, a second leg of the Great Recession, analogous to that of 1937. This risk is evident in the structure of global interest rates. At one level, U.S. Treasury bonds are now carrying the lowest yields in history, as gigantic sums of money seek a safe haven from this crisis. At another level, the weaker euro-zone countries, such as Spain and Italy, are paying stratospheric rates because investors are increasingly questioning their solvency. And there’s Greece, whose even higher rates signify its bankrupt condition. In addition, larger businesses and wealthy individuals are moving all of their cash and securities out of banks in these weakening countries. This undermines their financial systems. 423 Comments Weigh InCorrections? Personal Post The reason markets are battering the euro zone is that its hesitant leaders have not developed the tools for countering such pressures. The U.S. response to the 2008 credit market collapse is instructive. The Federal Reserve and Treasury took a series of huge and swift steps to avert a systemic meltdown. The Fed provided an astonishing $13 trillion of support for the credit system, including special facilities for money market funds, consumer finance, commercial paper and other sectors. Treasury implemented the $700 billion Troubled Assets Relief Program, which infused equity into countless banks to stabilize them. The euro-zone leaders have discussed implementing comparable rescue capabilities. But, as yet, they have not fully designed or structured them. Why they haven’t done this is mystifying. They’d better go on with it right now. Europe has entered this danger zone because monetary union — covering 17 very different nations with a single currency — works only if fiscal union, banking union and economic policy union accompany it. Otherwise, differences among the member-states in competitiveness, budget deficits, national debt and banking soundness can cause severe financial imbalances. This was widely discussed when the monetary treaty was forged in 1992, but such further integration has not occurred. How can Europe pull back from this brink? It needs to immediately install a series of emergency financial tools to prevent an implosion; and put forward a detailed, public plan to achieve full integration within six to 12 months. The required crisis tools are three: ●First, a larger and instantly available sovereign rescue fund that could temporarily finance Spain, Italy or others if those nations lose access to financing markets. Right now, the proposed European Stability Mechanism is too small and not ready for deployment. ●Second, a central mechanism to insure all deposits in euro-zone banks. National governments should provide such insurance to their own depositors first. But backup insurance is necessary to prevent a disastrous bank run, which is a serious risk today. ●Third, a unit like TARP, capable of injecting equity into shaky banks and forcing them to recapitalize. These are the equivalent of bridge financing to buy time for reform. Permanent stability will come only from full union across the board. And markets will support the simple currency structure only if they see a true plan for promptly achieving this. The 17 member-states must jointly put one forward. Both the rescue tools and the full integration plan require Germany, Europe’s strongest country, to put its balance sheet squarely behind the euro zone. That is an unpopular idea in Germany today, which is why Chancellor Angela Merkel has been dragging her feet. But Germany will suffer a severe economic blow if this single-currency experiment fails. A restored German mark would soar in value, like the Swiss franc, and damage German exports and employment. The time for Germany and all euro-zone members to get the emergency measures in place and commit to full integration is now. Global capital markets may not give them another month. The world needs these leaders to step up.